ICMR
Psoriasis
RESEARCH CENTER IN SPAIN (MADRID)
Clinical trials in psoriasis
Psoriasis is a chronic, systemic, immune-mediated inflammatory disease that mainly affects the skin, but can also involve other organs and body systems. In recent years, clinical research in this area has significantly improved the understanding of this pathology and improved knowledge about its overall management. For this reason, it remains essential to continue to develop research projects.
ICMR, an international medical research center based in Spain (Madrid), participates in rigorous clinical research projects, regulated and authorized by ethics committees and competent health authorities, which allow us to evaluate new treatments in different study phases. Our commitment is focused on advancing medical knowledge and developing the best therapeutic options for people with psoriasis and other immune-mediated diseases.
What is psoriasis?
Psoriasis is an autoimmune disorder that generates an uncontrolled activation of the immune system, causing chronic inflammation. Although its most visible manifestations are usually located on the skin, where red plaques covered with whitish scales appear, it is a pathology that can have a systemic impact.
In addition to skin lesions, psoriasis is associated with an increased risk of developing other diseases such as:
- Psoriatic arthritis (joint involvement).
- Cardiovascular disease.
- Fatty liver disease.
- Type 2 diabetes and metabolic syndrome.
- Inflammatory bowel disease.
- Emotional disorders such as anxiety and depression.
Psoriasis can present in various forms, although the most common types are plaque psoriasis, guttate psoriasis, inverse psoriasis, pustular psoriasis, and erythrodermic psoriasis—each with specific characteristics and distinct treatment needs.
Psoriasis is currently recognized as a systemic disease, meaning it has clinical implications that go beyond the skin. As such, it requires a comprehensive medical approach that addresses both the skin symptoms and the associated systemic impact.
What is a clinical trial?
A clinical trial is a regulated research study designed to evaluate the safety, tolerability, and efficacy of drugs, medical devices, therapeutic procedures, or preventive strategies.
All clinical trials conducted at ICMR Research are carried out under strict protocols, in full compliance with current legislation and international ethical standards. In addition, they are approved by independent ethics committees and health authorities, ensuring the highest level of protection for the rights, safety, and well-being of participants.
How are psoriasis clinical trials conducted?
Clinical studies on psoriasis are typically divided into several phases:
- Phase I: First evaluation in humans, focused on determining safety.
- Phase II: Assessment of efficacy and treatment response in a small group of patients.
- Phase III: Comparison of the new treatment with existing standard therapies in a larger patient population.
- Phase IV: Post-approval studies that provide further insights into how the treatment performs in real-world clinical practice.
Throughout the entire process, participants are closely monitored by a specialized medical team that ensures detailed and continuous follow-up.
Active clinical trials in psoriasis
CONDITION
Moderate to severe psoriasis in adolescents
Clinical study to evaluate treatments for adolescents with moderate to severe psoriasis.
Patients aged 12 to 18 years
Psoriasis affecting 10% or more of body surface area
CONDITION
Moderate to severe psoriasis in people over 40
Clinical study to evaluate treatments for moderate to severe psoriasis.
Patients aged over 40 years
Psoriasis affecting 10% or more of body surface area
Presence of one or more associated conditions, such as: type II diabetes mellitus, arterial hypertension, elevated cholesterol levels, overweight
The ICMR is a leading clinical research center in Europe
GENERAL INFORMATION
Psoriasis research project
At ICMR we carry out several research projects that seek to improve the understanding and treatment of psoriasis and other immune-mediated diseases. We participate in national and international studies, working in collaboration with high level clinical research networks.
Our projects may include:
- Evaluations of new biologic treatments for moderate to severe plaque psoriasis.
- Studies on innovative oral therapies.
- Research on biomarkers predictive of response to treatment.
- Analysis of the impact of psoriasis on systemic health.
All our research activity is carried out following the best clinical practices for our patients and under strict ethical, scientific and clinical quality standards.
Contributions of Clinical Research in Psoriasis
Participation in research projects contributes to the generation of high-quality medical knowledge. Through clinical trials, it is possible to:
- Evaluate and validate the efficacy and safety of new therapeutic alternatives.
- Develop treatments that address not only skin symptoms but also the systemic inflammatory component of the disease.
- Improve the understanding of associated comorbidities, such as cardiovascular risk or emotional impact.
- Advance personalized medicine strategies by tailoring treatments to each patient’s individual characteristics.
These advances not only benefit the scientific community but also help provide better management options for people living with psoriasis in the future.
About the available clinical studies
Some of the clinical trials currently open are investigating:
- New molecules designed to more specifically modulate the immune response.
- Therapeutic alternatives aimed at improving treatment adherence and patients’ quality of life.
- Treatments focused on reducing the systemic inflammation associated with psoriasis.
Participation requirements may vary depending on the specific study and may include factors such as age, type of psoriasis, previous treatments received, or overall health status.
Important considerations
Before deciding whether you would like to receive information about participating in a clinical study, it is important to consider the following points:
- Participation is voluntary and can be discontinued at any time without affecting your usual medical care.
- Not all investigational treatments guarantee clinical benefits; some studies may not have a direct therapeutic effect on the disease.
- All clinical trials are regulated and monitored by health authorities and independent ethics committees.
Our team is available to provide you with clear, confidential, and transparent information before you decide whether to take part in a research project.
Frequently Asked Questions About Psoriasis Clinical Trials
Does it cost anything to participate in a clinical study?
No. Treatments and medical evaluations related to the trial are typically covered by the study sponsor.
What safety measures are in place?
Clinical trials follow protocols approved by ethics committees and regulatory authorities, ensuring the protection of all participants.
What happens if I want to leave the study?
You can withdraw from the study at any time, without having to give a reason and without it affecting your future medical care.
How is my personal data protected?
Confidentiality is strictly maintained. All collected data is used exclusively for research purposes and in accordance with current data protection laws.
Where can I get more information?
If you would like to learn more about the psoriasis clinical trials we are conducting at ICMR Research, you can contact us confidentially to receive additional information:
- Through the contact form on our website.
- By emailing us at info@icmrresearch.com.
- By requesting information via our patient support phone lines.
We will respond to your questions in a personalized manner, always respecting your privacy and your right to make an informed, voluntary decision.
About us
ICMR is a reference center in Spain and Europe dedicated to the research of inflammatory and/or immune-mediated dermatological diseases. Promoted by the Pedro Jaén Foundation, our main objective is to transfer the highest level of science to patients who cannot find a solution to their dermatological problems with currently approved treatments.
Research areas
At ICMR we are prepared to develop research in all dermatological indications, with special attention to:
Psoriasis
We analyze genetic and immune factors to improve the approach to this disease.
Alopecia areata
We investigate the autoimmune basis and new options that stimulate hair growth.
Hidradenitis suppurativa
We analyze genetic and immune factors to improve the approach to this disease.
Atopic dermatitis
We explore the alteration of the skin barrier and the mediators that cause inflammation.
Nodular prurigo
We study the origin of severe itching and seek therapies to alleviate the discomfort.
Vitiligo
We investigate the autoimmune process that affects melanocytes and how to recover pigmentation.
Notalgia paresthetica
We study the neuropathic origin of itching and therapies to control the symptoms.