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Nodular prurigo is a skin disease of unknown origin that is usually associated with other skin pathologies, almost always atopic dermatitis, or with neurological, psychiatric, tumour or systemic disorders (infections, immune disorders, hypothyroidism, anaemia, liver or kidney failure, etc.).

Although the specific causes are not entirely clear, there is a clear hereditary component, as practically all those affected have a similar family history.

This skin disease is characterised by the appearance of skin lesions of varying size, similar in appearance to a welt but with a rough texture, which causes very intense itching. The number of these lesions varies from patient to patient and can range from a few nodules to several hundred, mainly on the shoulders, arms and legs, although they may also be distributed over the trunk, face or palms of the hands.

Although nodular prurigo can occur at any age, it is most common in adults between 20 and 60 years of age. In addition, almost 80% of patients with nodular prurigo also have asthma, allergy or eczema.

The intensity of itching is triggered and aggravated by simple causes such as heat, sweating or the mere rubbing of clothing, and can significantly interfere with the patient´s daily life. On the other hand, scratching can lead to excoriations and wounds which, in turn, can lead to infections and scarring.

Currently, there is no specific treatment for nodular prurigo, although different remedies are applied to relieve itching and inflammation, such as antihistamines, corticosteroids, calcineurin inhibitors, immunosuppressants, among others.