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Notalgia paresthetica was first described by the Greek researcher M. Astwazaturow in 1934. It is a chronic neurological disorder that affects the dorsal part of the back, typically the non-dominant side. Its incidence is higher in middle-aged women, although it can occur in individuals of all types.

It is characterized primarily by a very intense sensation of pain and/or itching, which may also be accompanied by paresthesias (tingling sensation), extreme sensitivity to cold, heat, pressure, contact, well as significant pain in response to stimuli that normally should not provoke it.

The diagnosis of this little-known pathology is carried out through clinical examination of the skin. As in most cases, notalgia paresthetica is evidenced by a dark spot on the skin of the area that itches or hurts. Additionally, a detailed medical history is usually compiled, where family history tends to appear, although not in all cases.

The causes of this neuropathy are not entirely clear, although it is considered to be related to a degenerative process of the central nervous system or peripheral entrapment of a nerve in that area. This disorder can lead to skin lesions resulting from intense scratching of the area, as well as a significant deterioration in the quality of life of the affected person due to the intense pain it causes.

Notalgia paresthetica is a rare condition considered chronic. To date, available treatments are aimed at relieving symptoms, primarily pain. Small trials with botulinum toxin type A have also been conducted, which appears to be an effective and safe alternative for alleviating itching, pain, and even skin hyperpigmentation in the long term compared to conventional pain treatments.

Clinical trials in progress for this disease


Name of the disease: Notalgia paraesthetica

Main inclusion criteria: Adult patients over 18 years old.